10x Genomics is expanding into paid data analysis software, a major change for a company that has historically included access to its software products along with its assays.
On Sept. 29, 10x announced the opening of an early-access program for Sentira, a cloud-based platform that offers GPU-accelerated data analysis pipelines, as well as visualization and collaboration tools it says can greatly accelerate research timelines.
The product employs hardware-accelerated algorithms pairing Nvidia’s graphics processing units (GPUs) with the rapids-singlecell analysis suite co-developed by Nvidia and the open-source scverse consortium, which maintains widely used single-cell analysis tools.
Under the early-access program, the spatial version of Sentira will be available for customers using 10x’s Xenium and Atera spatial instruments, with a planned launch as a paid product in early 2027. Pricing will be based on “consumption” with enterprise subscription options, 10x said, but did not disclose any additional pricing details.
How the pricing is set could be key to adoption, according to Nick Banovich, a researcher at the Translational Genomics Research Institute (TGen) who also runs a single-cell and spatial core lab.
“GPU-enabled analysis is critical,” he said. “For these big spatial datasets I’d say it becomes necessary. It’s not really tractable to have some of the front-end analyses take 10 to 20 days, especially if they are things you need to iterate on, like [cell] clustering.”
Beyond Sentira’s ability to quicken spatial data analysis, its collaboration capabilities are “a huge advantage we see,” 10x Cofounder and Chief Technology Officer Michael Schnall-Levin told Ion Genomics. Sentira also places its capabilities further downstream than 10x’s free Cell Ranger and Space Ranger suites have in the past. (According to 10x, Atera and Xenium generate “cell feature matrices” as part of the instrument run, obviating the need for Cell and Space Ranger.) For example, Sentira will have its own method for cell annotations, something that was only available as a service from 10x before.
Schnall-Levin said there are ”no current plans” to sunset any of 10x’s major software products.
The Sentira roadmap also includes support for single-cell sequencing data as well as agentic AI analysis and more capabilities further down the line from data generation; however, 10x did not provide a specific timeline for those additions.
“The idea is to cover the entire portfolio,” Schnall-Levin said.