10x Genomics, Cleveland Clinic Collaborate on Single-Cell, Spatial Diagnostics
The partners hope to better understand the mechanisms underlying therapeutic response in a number of major cancer types, including bladder cancer.
10x Genomics and the Cleveland Clinic are collaborating on new diagnostics for bladder cancer based on 10x’s single-cell and spatial technologies.
Under the multi-year collaboration, announced June 17, the partners will examine tumor samples from patients with advanced bladder cancer who are undergoing treatment with antibody-drug conjugates and immunotherapies. The study aims to identify clinically relevant biomarkers that may help predict response to treatment and support future diagnostic development for other tumor types.
They will begin by using 10x’s Flex Apex single-cell assays and Xenium spatial assays, eventually adding the new Atera instrument. Financial and other terms of the deal were not disclosed.
“This collaboration has the potential to shed new light into the mechanisms underlying therapeutic response in a number of major cancer types,” Timothy Chan, chair of the Cleveland Clinic’s department of cancer sciences, said in a statement.
The deal is the latest step towards diagnostics and clinical applications for 10x’s technologies for gene expression and protein analysis. The effort to build data to support its use in medicine is in full swing. In January, the company announced three new collaborations with a clinical focus and revealed it is planning to open a CLIA-certified lab next year.
10x and the Cleveland Clinic said they expect to generate a multimodal dataset based on single-cell gene expression profiling, spatial gene expression, and protein measurements, that will link single-cell and spatial insights with clinical outcomes.
Specifically they plan to analyze the tumor microenvironment, immune cell infiltration, and expression of therapeutic targets to better understand mechanisms of response and resistance.
Shares of 10x Genomics rose 5 percent in morning trading on June 17.
